Bioactive Small Molecules
Medchemexpress LLC Imd-0560 | 439144-66-8 | MFCD | 98.7% | 428.12 g·mol⁻¹ | C15H8BrF6NO2 | 10 MG
IMD-0560 is a small-molecule inhibitor of IκB kinase β (IKKβ) developed for research applications. It modulates the NF-κB signaling pathway and has been used in preclinical studies investigating inflammation and cancer-related processes. The material is supplied as a characterized research reagent with supporting analytical documentation.
- Selective inhibition of IκB kinase β suitable for pathway and target validation studies.
- High purity for reproducible in vitro and cell-based assays.
- Available as solid and as a solution formulation for flexible experimental use.
- Provided with safety data sheet, certificate of analysis, and analytical reports.
- Intended for research use only; not for human or clinical use.
Cayman Chemical ANTIBODY NItrofen 100mg
A herbicide with potent teratogenic activity in rats and mice; induces bilateral pulmonary hypoplasia and an immature lung architecture in fetal rats and mice
Cayman Chemical ANTIBODY TP-4748 50mg
A heterocyclic building block; has been used in the synthesis of prolyl-tRNA synthase inhibitors
Cayman Chemical ANTIBODY VoacngIn 1mg
An indole alkaloid with diverse activities; inhibits the growth of M. tuberculosis, M. avium, and M. kansasii (MICs = 50, >200, and 100 μg/mL, respectively); dose-dependently reduces membrane current of HEK293 cells expressing hERG at 0.01-100 μM; displaces the hERG ligand dofetilide (Ki = 3.9 μM); suppresses agonist-stimulated activation of TRPV1 and TRPM8 (IC50s = 50 and 9 μM, respectively); activates TRPA1 and stimulates calcium influx (IC50 = 8 μM); inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity at 2 and 4 μg per egg
Cayman Chemical FumIquInazolIn D 5mg
A fungal metabolite with antibacterial and antifungal properties; active against Gram-positive and Gram-negative bacteria (MICs = 8-16 UG/ml); active against F. solani and C. albicans fungi (MICs = 32 and 64 UG/ml)
Cayman Chemical ANTIBODY ElIprodIl 50mg
A non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents; selective for NR2B subunit-containing receptors (IC50 = 1 µM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits
Medchemexpress LLC HY-N6850 5mg Medchemexpress, Calenduloside E CAS:26020-14-4 Purity:>98%
Medchemexpress, HY-N6850 5mg Calenduloside E CAS:26020-14-4 Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical DItyrosInhydrochlorIde 5mg
A protein oxidation product; intragastric administration decreases hippocampal expression of the NMDA receptor subunits Nr1, Nr2a, and Nr2b and induces memory impairments in a novel object recognition test in mice at 320 UG/kg per day; increases fasting blood glucose levels and decreases plasma insulin levels and pancreatic expression of the insulin synthesis-related genes Ins2, Pdx1, and MafA in mice; increased levels are positively correlated with various diseases
![Medchemexpress LLC [(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylben | 1652629-23-6 | MFCD32688762 | 99.1% | 473.57 g/mol | C27H31N5O3 | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239471.png-250.jpg)
Medchemexpress LLC [(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylben | 1652629-23-6 | MFCD32688762 | 99.1% | 473.57 g/mol | C27H31N5O3 | 100MG
GSK484 is a selective, reversible inhibitor of protein-arginine deiminase 4 (PAD4) used as a chemical probe in inflammation and rheumatoid arthritis research. It reduces inflammation and joint destruction in collagen-induced arthritis models and modulates TNF-α expression, and is supplied as a high-purity solid for biochemical and cellular studies.
- Selective, reversible PAD4 inhibitor suitable for biochemical assays.
- Demonstrated activity in arthritis and inflammation models.
- High purity (99.1%) for research applications.
- Molecular weight 473.57 g/mol; formula C27H31N5O3.
- Supplied as a 100 mg solid pack for laboratory use.
Cayman Chemical ANTIBODY ML-221 25mg
An APJ receptor antagonist (IC50 = 4.8 μM); selective for APJ over AT1 (IC50 = >78 μM); antagonizes apelin 13-induced activation of APJ in cAMP and β-arrestin recruitment assays (IC50s = 0.7 and 1.75 μM, respectively); inhibits proliferation and angiogenesis in Mz-ChA-1 cholangiocarcinoma cells from 5-15 μM; reduces tumor growth in a Mz-ChA-1 mouse xenograft model at 150 μg/kg; reduces sciatic CCI-induced mechanical allodynia and heat hyperalgesia in rats at 10 μg/animal; inhibits pathological angiogenesis and enhances normal vessel recovery in retinal ischemic regions in a mouse model of oxygen-induced retinopathy
Medchemexpress LLC Mitochondria degrader-1 | 2241669-05-4 | 95.1% | 758.30 | 25 MG
Mitochondria degrader-1 is a potent compound engineered to induce the degradation of injured mitochondria through the autophagy mechanism. This degrader facilitates the removal of damaged mitochondria, making it a valuable tool for research in various disease areas.
- Valuable tool for research in various disease areas
- Applications span across studies related to neurodegenerative diseases, cancer, inflammatory conditions, age-related diseases, metabolic disorders, mitochondrial diseases, and Down's disease
Cayman Chemical ANTIBODY NCT-502 1mg
A selective PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC50 = 3.7 µM); reversibly blocks the production of glucose-derived serine in cells
Cayman Chemical ANTIBODY RIfabutIn 10mg
A rifamycin antibiotic; active against 81 clinical isolates of H. pylori (MIC50 = 0.25 UG/ml), as well as S. aureus, S. pyogenes, and C. trachomatis (MICs = 0.004, 0.005, and ~0.008 UG/ml, respectively); active against 302 strains of M. tuberculosis at 0.5 UG/ml; inhibits the activity of RNAP; reduces the number of spleen, lung, and liver CFUs in mouse models of disseminated MAC infection
Cayman Chemical ANTIBODY EGTA 50g
A chelating agent; selective for calcium over magnesium with Kapp values for calcium ranging from 6.93 to 10.7 x 105 M-1 in various buffers at pH 6.8 and 20°C; inhibits apoptosis induced by thapsigargin in isolated rat thymocytes at 5 mM; has been used as an irrigation agent to remove the smear layer from the pulp canal wall on extracted human teeth; intranasal administration enhances adenovirus-mediated gene transfer of LacZ to the trachea and main bronchi in mice by 8-fold
TARGETMOL CHEMICALS INC T-5224 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. T-5224 is a transcription factor c-Fos/AP-1 inhibitor which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. purity: 99%